Elucidating the mechanism
m RNA transcripts are abundant in GABAergic interneurons of the hippocampus, indirectly reflecting the expression of these receptors and elucidating the established effect of cannabinoids on memory.
CB1 and THC are deactivated by the phytocannabinoid tetrahydrocannabivarin (THCV).
Effects may vary based on the site of cannabinoid application, input from higher cortical centers, and whether drug application is unilateral or bilateral.
The role of the CB receptor in the regulation of motor movements is complicated by the additional expression of this receptor in the cerebellum and neocortex, two regions associated with the coordination and initiation of movement.
is heavily expressed in layers 1 and 2 of the spinal cord dorsal horn and in lamina 10 by the central canal.
Dorsal root ganglion also express these receptors, which target a variety of peripheral terminals involved in nociception.
Cannabinoids also likely play an important role in the development of memory through their neonatal promotion of myelin formation, and thus the individual segregation of axons.